What’s Next When Clomid Does Not Achieve Ovulation






VN:F [1.9.16_1159]
Rating: 0.0/5 (0 votes cast)

1. What Is Clomid?

Clomid is a very popular and well known fertility drug. It has been in use for more than thirty years and it is very successful in many women. Clomid is very good at inducing ovulation in women who have ovulation problems.


Clomid is usually taken for five days in a row, beginning on day 3, day 4, or day 5 of a woman’s menstrual cycle. Clomid is usually very well tolerated and has minimal side effects, which makes it a great choice for many women.

2. What If Clomid Doesn’t Work?

As mentioned before, Clomid is usually very well tolerated and very good at inducing ovulation in most women. However, it isn’t always successful. Clomid is usually successful in inducing ovulation around 75 percent of the time.


So, what happens in the other 25 percent of women? In some women, the only problem might be that the dosage of Clomid was too low. Therefore, if doctors are able to simply increase the dosage of Clomid, women might be able to see more success.


Doctors might try to increase the dosage until they see an improvement. However, if doctors don’t see an improvement, it might be said that a woman is Clomid Resistant.

3. What’s Next?

If  a woman’s doctor thinks that she is Clomid resistant, it depends on what the doctor thinks the cause is as to what form of treatment will come next. For example, if the doctor thinks that PCOS is the cause of the Clomid resistance, doctors might prescribe the drug Metformin, commonly used for insulin resistance in diabetics.


If a doctor thinks that a woman’s weight and BMI are the cause of her Clomid resistance, she might start a diet and exercise plan to lose weight. Some doctors also recommend a woman take birth control pills for a few months before trying Clomid again in order to increase the likelihood of Clomid working.

4. What’s After That?

If a woman tries all of the options that her doctor recommends and she still is not ovulating properly, the doctor might suggest the use of injectable hormones in order to boost the chances of ovulation. Injectable hormones are much stronger than Clomid, but can also have more potent side effects.


These injectable hormones, known as gonadotropins, are often a bit more expensive than other options but they can really work well in some cases. There is no “one size fits all” fix for women with Clomid resistance, but usually, when a woman works with her doctor, she can come up with a great alternative solution.

Regina Ledoux, RN, CNM

Ms. Ledoux began her career as an ObGyn nurse practitioner prior to becoming a practicing midwife in the Santa Cruz community. Working together with ObGyn physicians in her own practice, she has over 20 years experience in women's health, pregnancy and childbirth.